Subscribe to receive this FREE daily commentary directly in your email
The S&P 500
The S&P 500 is now just 9 points away from our 2,600 target. The question is where the market goes from here. The real problem is the path in which the index takes. Does it follow the blue or green trend lines higher from current levels? The upper blue line is a long-term resistance level that finds its origin to back to 2010 and last came into play in the fall of 2015, when the market went through a period or sideways trading with extreme levels of volatility.
[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_tweetmeme type=”follow” follow_user=”michaelmottcm” show_followers_count=”true” large_button=”true”][/vc_column][/vc_row] Get This In Your E-Mail Subscribe
Meanwhile the green trend line finds it orgin back to the February 2016 lows after coming after the period of volatility. At this point it could be hard to say which way it goes, but it would not surprise me to see a pull-back of sorts sending the index back to 2550 region or perhaps the 2,500 level. It would certainly be nothing catastrophic and would likely be quiet healthy, in the range of 4 percent.
[poll id=”8″]
It would set up and an eventual move towards 2,700 in the early months of 2018. Given the estimated earnings growth, and expectations for full-year earnings in 2018 of $131.36. I still think the index could rise to 3,100, giving it a PE ratio of roughly 23 times 2018 earnings. At 23 times earnings, the S&P 500 would be trading at its historical PE ratio of since 2015.
S&P 500 Earnings Per Share TTM Forward Estimate data by YCharts
Premium Content: Benefits include the ability to reach out to Mike with questions through a chat room, direct message, or comments.Â
Analysis Of Acadia’s Phase II Data, Plus QCOM/AVGO
NXP Would Benefit From Broadcom Buying Qualcomm
Cracking The Productivity Mystery
Productivity Issue In One Chart
Facebook, Alibaba, Apple Earning Preview
What Good Are The Analyst Worth!
 Acadia
Acadia shares got slammed today, after Leerink questioned the result of Acadia’s Phase 2 Alzheimers Disease Psychosis trial results, which were released on Friday, November 3. Firstly, having read the press release and reviewing the note, it would seem there are questions regarding the separation between the placebo arm and the pimavanserin arm at week 6. First, there could be any number of reason why the placebo arm retraced at week 6. Second, when reviewing data from the trial in Parkinson Disease Psychosis, the same effect happen in week six as well, it is very clear in the diagram on page 5 of the Lancet report.
Second, Acadia’s ADP data from Friday shows a Cohen’s d score of .32, which falls in the small to medium range for effect size, for the overall study, while the group with severe psychosis showed a substantial effect size of 0.72. There have been plenty of other atypical antipsychotics that failed miserable using the same NPH-NH scale, so the results if anything should be encouraging.
Additionally, the advisory committee for pimavanserin’s approval for Parkinson Disease Psychosis also taught us a couple of things as well. As some argue that meaningfulness could be measured as a change from baseline, not just versus placebo, page 273.Â
As for the comparison with ALKS 5461, a drug for the treatment of depression has about the only thing in common with pimavanserin in that they are both for psychiatric indications. But when reviewing the data for ‘5461 one can find the can shifts in both the placebo arm and the drug arm for various reasons.
Again, ADP is, and Dementia-related psychosis is a population with no currently approved treatment options, and the trial design in phase III is very different from the Phase II results. The Phase III study is will measure time from randomization to relapse for 26 weeks, and the secondary measure will be time until discontinuation. The results are not expected until the year 2020.
So while investors were bearish on the name, the result of Phase III will not have any meaning for the company for many years, while the drug sales in Parkinson Disease Psychosis will be the driving force between now and then.
Meanwhile, the street should be focused on the ability for pimavanserin in depression and schizophrenia which are currently due in the fall and winter of 2018-2019. Afterall, pimavanserin is a Selective Serotonin Inverse Agonist targeting the 5HT-2A receptor.  While also having positive results in schizophrenia when tried in combination with Risperdol and Haloperidol way back when.
That is all for today.
Free Articles Written By Mike:
Broadcom’s Bid Could Spark A Wave of Chipmaker Takeovers
SNAP’s Stock Rebound Could Last If It Fires Up Growth
Apple Crushed 4Q Earnings, Chip Suppliers To Benefit
Elliot Management Steps Up Efforts to Raise NXP Bid Price
Chipotle Shares Could Fall 20 Percent Further
Broadcom’s Raised Forecast Is Great News For Chip Stocks
Starbucks 4Q Earnings Could Surprise Investors
Apple Shares Are Set Up For Post-Earnings Fall
Apple’s Chip Suppliers Are Breaking Out
Amazon, Alphabet And Microsoft Simply Crushed It
Why Mastercard’s Stock Could Rise 15%
Why Amazon’s Earnings Aren’t As Strong As They Look
Qualcomm Deal With NXP Will Eventually Get Done – M…
Celgene and Biogen May Be Signalling A Biotech Bottom
AMD Could Rise 10% Despite Results, Trades Indicate
Why Tesla’s Stock Is Breaking Down
Why Is McDonald’s Valued Like a Big Tech Stock?
Why Biogen May Sink Biotech Sector As Earnings Beat
Netflix Stock Likely to Rise as EPS Estimates Jump
Bank of America Could Rise Nearly 50%: Technical Analysis
AMD Could Break Out After Results
Qualcomm’s Bid For NXP Still Lacks Investor Support
Celgene’s Sharp Sell-Off Is Likely Overdone
Procter & Gamble Continues To Have Two Big Problems
GE: Getting Excited For The Future
Why IBM’s Big Stock Rally Won’t Last
Allergan Shares On The Verge Of Further Breakdown
We offer a lot of great commentaries all week talking about the major and relevant market events. Be sure to subscribe to get this all and of all free commentaries sent directly to your inbox or follow us on Twitter.
-OR-
[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_tweetmeme type=”follow” follow_user=”michaelmottcm” show_followers_count=”true” large_button=”true”][/vc_column][/vc_row]
Michael Kramer and the clients of Mott Capital own shares of ACAD and ALKS
Mott Capital Management, LLC is a registered investment adviser. Information presented is for educational purposes only and does not intend to make an offer or solicitation for the sale or purchase of any specific securities, investments, or investment strategies. Investments involve risk and unless otherwise stated, are not guaranteed. Be sure to first consult with a qualified financial adviser and/or tax professional before implementing any strategy discussed herein. Upon request, the advisor will provide a list of all recommendations made during the past twelve months. Past performance is not indicative of future.
#acadia $acad $spy $spx #sp500
Subscribe to receive this FREE daily commentary directly in your email
Charts used with the permission of Bloomberg Finance L.P. This report contains independent commentary to be used for informational and educational purposes only. Michael Kramer is a member and investment adviser representative with Mott Capital Management. Mr. Kramer is not affiliated with this company and does not serve on the board of any related company that issued this stock. All opinions and analyses presented by Michael Kramer in this analysis or market report are solely Michael Kramer’s views. Readers should not treat any opinion, viewpoint, or prediction expressed by Michael Kramer as a specific solicitation or recommendation to buy or sell a particular security or follow a particular strategy. Michael Kramer’s analyses are based upon information and independent research that he considers reliable, but neither Michael Kramer nor Mott Capital Management guarantees its completeness or accuracy, and it should not be relied upon as such. Michael Kramer is not under any obligation to update or correct any information presented in his analyses. Mr. Kramer’s statements, guidance, and opinions are subject to change without notice. Past performance is not indicative of future results. Neither Michael Kramer nor Mott Capital Management guarantees any specific outcome or profit. You should be aware of the real risk of loss in following any strategy or investment commentary presented in this analysis. Strategies or investments discussed may fluctuate in price or value. Investments or strategies mentioned in this analysis may not be suitable for you. This material does not consider your particular investment objectives, financial situation, or needs and is not intended as a recommendation appropriate for you. You must make an independent decision regarding investments or strategies in this analysis. Upon request, the advisor will provide a list of all recommendations made during the past twelve months. Before acting on information in this analysis, you should consider whether it is suitable for your circumstances and strongly consider seeking advice from your own financial or investment adviser to determine the suitability of any investment.
Liquidity Strains Persist Creating Dangerous Market Back Drop
Mott Capital's Market Chronicles 8 hours ago